Courses
- GENE 202: Human Genetics
Utilizes lectures and small group discussions to design a working
knowlege of human genetics as applicable to clinical medicine and
research. Basic principles of inheritance, risk assessment, and
population genetics, illustrated by using clinical examples drawn from
diverse areas of medical genetics practice including prenatal,
pediatric, adult and cancer genetics. Practical aspects of molecular
and cytogenetic diagnostic methods emphasized. Existing and emerging
treatment strategies for single gene disorders also
covered. Prerequisites: biochemistry; basic genetics.
Terms: Aut | Units: 4 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Bernstein, J.
- GENE 203: Advanced Genetics (BIO 203, DBIO 203)
For graduate students in Bioscience programs; may be appropriate for
graduate students in other programs. Focused on application of the
genetics toolbox to problems in modern biology research. Topics
covered include analytic methods, genetic manipulation, genome
analysis, and human genetics. Lectures and faculty-led discussion
sections with evaluation of papers. Students with minimal experience
in genetics should prepare by working out problems in college level
textbooks.
Terms: Aut | Units: 4 | Grading: Medical Option (Med-Ltr-CR/NC)
- GENE 209: Current Topics in Human, Population, and Statistical Genomics
Intensive seminar/workshop. Topics, drawn from current and past
literature, may include: assessing and population genetic analysis of
genomic variation; genome-to-phenome mapping; reconstructing
demographic history from genome sequence data; domestication genomics;
host-pathogen genome evolution; detecting signatures of selection;
experimental design in human genetics; linkage and association
mapping; ethical and social issues in human, plant, and animal
genetics research. Emphasis on analysis and logic or experimental and
observational genomics research. Faculty-led discussion with
evaluation of response papers, problem sets, and intensive course
project. May be repeated... more description for GENE 209 »
Terms: Win, Spr | Units: 2 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Bustamante, C.
- GENE 210: Genomics and Personalized Medicine Class URL
Principles of genetics underlying associations between genetic
variants and disease susceptibility and drug response. Topics include:
genetic and environmental risk factors for complex genetic disorders;
design and interpretation of genome-wide association studies;
pharmacogenetics; full genome sequencing for disease gene discovery;
population structure and genetic ancestry; use of personal genetic
information in clinical medicine; ethical, legal, and social issues
with personal genetic testing. Hands-on workshop making use of
personal or publicly available genetic data. 2 units lecture only; 3
units lecture and workshop. Prerequisite: GENE 202 or 203.
Terms: Spr | Units: 2-3 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Kim, S.
- GENE 211:
Genomics Class URL
Genome evolution, organization, and function; technical,
computational, and experimental approaches; hands-on experience
with representative computational tools used in genome science;
and a beginning working knowledge of PERL.
Terms: Win | Units: 3 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Cherry, J.M. ; Sherlock, G. ; Snyder, M.
- GENE 222: Method and Logic in Experimental
Genetics Class URL
For graduate students only. How experimental strategies are applied to
biological questions irrespective of discipline boundaries. Examples
include purifying activities from complex mixtures, localizing
molecules in space and time, discovering macromolecular interactions,
inferences from sequence similarity, using structure to elucidate
function, and applying genomics to biological problems. Weekly
discussion of two representative papers selected by faculty and a
student presentation of a third paper which illustrate principles of
biochemistry and cell and molecular biology, and the historical
context of important scientific advances.
Terms: Win | Units: 3 | Grading: Letter (ABCD/NP)
Instructors: Baker, J. ; Pringle, J.
- GENE 235: C. Elegans Genetics
Genetic approaches to C. elegans, practice in designing experiments
and demonstrations of its growth and anatomy. Probable topics include:
growth and genetics, genome map and sequence, mutant screens that
start with a desired phenotype, reverse genetics and RNAi screens,
genetic duplications, uses of null phenotype non-null alleles, genetic
interactions and pathway analysis, and embryogenesis and cell
lineage. Focus of action, mosaic analysis, and interface with
embryological and evolutionary approaches.
Terms: Win | Units: 2 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Fire, A.
- GENE 244: Introduction to Statistical Genetics
Statistical methods for analyzing human genetics studies of Mendelian
disorders and common complex traits. Probable topics include:
principles of population genetics; epidemiologic designs; familial
aggregation; segregation analysis; linkage analysis;
linkage-disequilibrium-based association mapping approaches; and
genome-wide analysis based on high-throughput genotyping
platforms. Prerequisite: STATS 116 or equivalent or consent of
instructor.
Terms: alternate years, given next year | Units: 3 | Grading: Medical
Option (Med-Ltr-CR/NC)
- GENE 245: Computational Algorithms for Statistical Genetics (STATS345)
Computational algorithms for human genetics research. Topics include:
permutation, bootstrap, expectation maximization, hidden Markov model,
and Markov chain Monte Carlo. Rationales and techniques illustrated
with existing implementations commonly used in population genetics
research, disease association studies, and genomics
analysis. Prerequisite: GENE 244 or consent of instructor.
Terms: alternate years, given next year | Units: 2-3 | Grading:
Medical Option (Med-Ltr-CR/NC)
- GENE 271: Human Molecular Genetics
For genetic counseling students, graduate students in genetics,
medical students, residents, and postdoctoral fellows interested in
the practice of medical genetics. Gene structure and function; the
impact of mutation and polymorphism as they relate to developmental
pathways and health and human disease; population based genetics;
approaches to the study of complex genetic conditions; GWAS and genome
sequencing technologies; gene therapy, proteomics, stem cell biology,
and pharmacogenetics. Undergraduates require consent of instructor and
a basic genetics course.
Terms: Aut | Units: 4 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Francke, U. ; Kwan, A.
- GENE 272: Introduction to Medical Genetics
For genetic counseling students, graduate students in human genetics,
medical students, residents, and fellows; undergraduates with consent
of instructor. Principles of medical genetics including taking a
family history, modes of inheritance, and mathematical principles of
medical genetics (Bayes theorem, population genetics). An additional
problem set is required for 3 units.
Terms: Aut | Units: 2-3 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Hudgins, L. ; Ormond, K.
- GENE 273: Introduction to Clinical Genetics Testing
For genetic counseling students, graduate students in genetics,
medical students, residents, and fellows; undergraduates with consent
of instructor. Uses a combination of case based approach and didactic
lectures to introduce the laboratory concepts of cytogenetics and
molecular genetics, and illustrate common genetic conditions that are
diagnosed through such testing, introducing students to skills in case
preparation, management and presentation. An additional problem set is
required for 3 units.
Terms: Aut | Units: 2-3 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Hudgins, L. ; Kwan, A.
- GENE 274A: A Case Based Approach to Clinical Genetics
For genetic counseling students, graduate students in genetics,
medical students, residents and fellows. Case-based scenarios and
guest expert lectures. Students learn skills in case preparation,
management, and presentation, as well as content around common genetic
disorders.
Terms: Win | Units: 2 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Hudgins, L. ; Kwan, A.
- GENE 274B: A Case Based Approach to Clinical Genetics
For genetic counseling students, graduate students in genetics,
medical students, residents, and fellows. Case-based scenarios and
guest expert lectures. Students learn skills in case preparation,
management, and presentation, as well as content around common genetic
disorders.
Terms: Spr | Units: 2 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Hudgins, L. ; Ormond, K.
- GENE 278: Prenatal Genetic Counseling
Internet-based course for genetic counseling students, graduate
students in genetics, medical students, residents, and fellows;
genetic counseling students should take this course in conjunction
with their initial prenatal genetics rotation. Topics include prenatal
genetic screening and diagnosis in the first and second trimesters,
ultrasound, teratology, and genetic carrier screening.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical
Satisfactory/No Credit
Instructors: Ormond, K.
- GENE 279: Pediatric and Adult Genetic Counseling
Internet-based course for genetic counseling students, graduate
students in genetics, medical students, residents, and fellows;
genetic counseling students should take this course in conjunction
with their initial general genetics rotation. Topics include: common
genetic conditions; assessment of child development and medical
history in the context of a genetic workup; dysmorphology; development
of a differential diagnosis; and resources for case management and
family support.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical
Satisfactory/No Credit
Instructors: Kwan, A. ; Ormond, K.
- GENE 280: Metabolic Genetic Counseling
Internet-based course for genetic counseling students, graduate
students in genetics, medical students, residents, and fellows;
genetic counseling students should take this course in conjunction
with their metabolic genetics rotation. Topics include: overview of
metabolic diseases; common pathways; diagnosis, management, and
treatment of metabolic disorders; and newborn screening.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical
Satisfactory/No Credit
Instructors: Kwan, A. ; Ormond, K.
- GENE 281: Cancer Genetic Counseling
Internet-based course for genetic counseling students, graduate
students in genetics, medical students, residents, and fellows;
genetic counseling students should take this course in conjunction
with their initial cancer genetics rotation. Topics include: cancer
biology and cytogenetics; diagnosis and management of common cancer
genetic syndromes; predictive testing; psychology of cancer genetic
counseling; and topics recommended by ASCO guidelines.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical
Satisfactory/No Credit
Instructors: Ormond, K.
- GENE 284: Medical Genetics Seminar
Presentation of research and cases. Students enrolling for 2 units
also attend and report on external seminars. May be repeated for
credit.
Terms: Aut, Win, Spr | Units: 1-2 | Repeatable for credit | Grading:
Medical Option (Med-Ltr-CR/NC)
Instructors: Kwan, A.
- GENE 285A: Genetic Counseling Seminar
Year-long seminar primarily for genetic counseling students. Autumn:
basics of medical communication; crosscultural and disability
sensitive communication about genetics, and principles of providing
genetic counseling. Winter: the impact of chronic illness and genetic
disease in a developmental manner. Spring: applying therapeutic
counseling approaches to the practice of genetic
counseling. Undergraduates may enroll in Autumn Quarter with consent
of instructor.
Terms: Aut | Units: 2-3 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Ormond, K.
- GENE 285B: Genetics Counseling Seminar
Year-long seminar primarily for genetic counseling students. Autumn:
basics of medical communication; crosscultural and disability
sensitive communication about genetics, and principles of providing
genetic counseling. Winter: the impact of chronic illness and genetic
disease in a developmental manner. Spring: applying therapeutic
counseling approaches to the practice of genetic
counseling. Prerequisite: GENE 285A.
Terms: Win | Units: 2-3 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Ormond, K.
- GENE 285C: Genetic Counseling Seminar
Year-long seminar primarily for genetic counseling students. Autumn:
basics of medical communication; crosscultural and disability
sensitive communication about genetics, and principles of providing
genetic counseling. Winter: the impact of chronic illness and genetic
disease in a developmental manner. Spring: applying therapeutic
counseling approaches to the practice of genetic
counseling. Prerequisite: 285 A/B.
Terms: Spr | Units: 2-3 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Ormond, K.
- GENE 286: Advanced Genetic Counseling Seminar
For genetic counseling students only. Psychosocial issues associated
with genetic counseling cases are discussed through presentation of
cases that students have seen throughout their training. Professional
development topics including: the expanding roles of genetic
counselors; billing, reimbursement, and licensing; the role of genetic
counseling in the changing healthcare system; the incorporation of
genetics into all areas of medicine and public health; and
implications of direct-to-consumer genetic testing. Must be taken for
3 quarters. Prerequisites: GENE 285 A,B,C and 276.
Terms: Aut | Units: 2 | Repeatable for credit | Grading: Letter or
Credit/No Credit
Instructors: Kwan, A. ; Ormond, K.
- GENE 286B: Advanced Genetic Counseling Seminar
Continuation of GENE 286A. For genetic counseling students
only. Psychosocial issues associated with genetic counseling cases are
discussed through presentations of cases that students have seen
throughout their training. Professional development topics including:
the expanding roles of genetic counselors; billing, reimbursement, and
licensing; the role of genetic counseling in the changing healthcare
system; the incorporation of genetics into all areas of medicine and
public health; and implications of direct-to-consumer genetic
testing. Prerequisites: GENE 285 A,B,C and 276.
Terms: Win | Units: 2 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: Kwan, A. ; Ormond, K.
Independent Study Courses
- GENE 260: Supervised Study
Genetics Graduate students lab research from the first quarter until candidacy has been filed. (Usually from quarter 1 through quarter 6).
- GENE 299:
Directed Reading
Reading directed by Genetics Faculty. (Often to fulfill a course requirement or for a student to become more knowledgeable in a particular area of study.)
Note: If Directed Reading is taken to fulfill a course requirement, a memo is required stating that the student has taken Directed Reading the [state the quarter] and has successfully completed the requirement for [course number].
- GENE 399:
Individual Research
Genetics Graduate Students research to be registered for, after quals have been passed, candidacy has been filed and until the student is registered TGR.
- GENE 801:
TGR Dissertation
- GENE 802:
TGR Dissertation
To be registered for on your final quarter, the quarter the dissertation is submitted. Registration after a student has filed for Candidacy, completed the Department required courses, and completed the university residency requirements. There are no units provided for TGR registration. Therefore, no courses can be taken unless the student pays tuition.
Note: Advisors must grade this course:
"N" means the work is satisfactory,
"N-" means the work is unsatisfactory,
Two "N-" grades in succession means that the student's record is automatically referred to the Graduate Dean and this is grounds for dismissal.
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